If you take time off, you obtain permission not to go to work for a short period of time. Mitchel's schedule had not permitted him to take time off She took two days off work
If you take a garment off, you remove it. He wouldn't take his hat off She took off her spectacles. put on
If something such as a product, an activity, or someone's career takes off, it suddenly becomes very successful. In 1944, he met Edith Piaf, and his career took off
mimic or imitate, especially in an amusing or satirical manner; "This song takes off from a famous aria"