use up (resources or materials); "this car consumes a lot of gas"; "We exhausted our savings"; "They run through 20 bottles of wine a week"
To empty or unload, as the vessels of human system, by bloodletting or by medicine
To deplete a stock or amount of something means to reduce it. substances that deplete the ozone layer + depleted de·plet·ed Robert E. Lee's worn and depleted army. + depletion de·ple·tion the depletion of underground water supplies. to reduce the amount of something that is present or available (depletus, past participle of deplere, from plere )