loss of heterozygosity

listen to the pronunciation of loss of heterozygosity
Английский Язык - Английский Язык
loh
A genetic event that can occur in the dividing cells of a diploid organism heterozygous for one or more markers, in which a daughter cell becomes homozygous or hemizygous for one or more alleles through mitotic recombination, deletion, or gene conversion "Loss of heterozygosity (LOH)" events are often important steps in tumor progression See the animation of this concept by Robert J Huskey at the Univeristy of Virginia
DNA loss that occurs early in tumor development The extent of loss can range from a few million nucleotide pairs to an entire chromosome Specific cancers tend to lose certain chromosomal regions, resulting in characteristic patterns of LOH
Describes a locus (or loci) at which a deletion or other process has converted the locus from heterozygosity to homozygosity or hemizygosity Phenomenon can lead to cancers by loss of tumor suppressor genes
loss of heterozygosity
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