kötücül anemi

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(Tıp) pernicious anemia
A severe form of anemia caused by vitamin B12 insufficiency
a chronic progressive anemia of older adults; thought to result from a lack of intrinsic factor (a substance secreted by the stomach that is responsible for the absorption of vitamin B12)
A severe anemia most often affecting older adults, caused by failure of the stomach to absorb vitamin B and characterized by abnormally large red blood cells, gastrointestinal disturbances, and lesions of the spinal cord. Slow-developing disease in which vitamin B12 (see vitamin B complex) deficiency impairs red-blood-cell production. It can result from a diet lacking in vitamin B12 or when intrinsic factor, a substance needed for intestinal absorption of B12, either is not produced by stomach cells or cannot bind to the vitamin. It causes weakness, waxy pallor, shiny tongue, and stomach, intestinal, and neurological problems. Its slow development can allow anemia to become very severe by the time of diagnosis. Monthly B12 injections into muscle soon reverses the anemia, but the injections must be continued for life
{i} severe form of anemia affecting mostly older people
kötücül anemi
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