the act of disturbing the mind or body; "his carelessness could have caused an ecological upset"; "she was unprepared for this sudden overthrow of their normal way of living"
The act of deranging or putting out of order, or the state of being deranged; disarrangement; disorder; confusion; especially, mental disorder; insanity
To put out of place, order, or rank; to disturb the proper arrangement or order of; to throw into disorder, confusion, or embarrassment; to disorder; to disarrange; as, to derange the plans of a commander, or the affairs of a nation