Şiddetli bir donmanın ardından kangrenle enfekte olduktan sonra Tom'un ayağı kesilmek zorunda kaldı. - Tom's foot had to be amputated after it had become infected with gangrene following a severe frostbite.
The act of mortifying, or the condition of being mortified The death of one part of an animal body, while the rest continues to live; loss of vitality in some part of a living animal; gangrene
(Christianity) the act of mortifying the lusts of the flesh by self-denial and privation (especially by bodily pain or discomfort inflicted on yourself)