To madden a person or animal means to make them very angry. He knew that what he was saying did not reach her. And the knowledge of it maddened him = infuriate. to make someone very angry or annoyed
make mad; "His behavior is maddening" drive up the wall; go on someone's nerves cause to go crazy; cause to lose one's mind
drive up the wall; go on someone's nerves cause to go crazy; cause to lose one's mind
marked by extreme anger; "the enraged bull attached"; "furious about the accident"; "a furious scowl"; "infuriated onlookers charged the police who were beating the boy"; "could not control the maddened crowd"
If you describe something as maddening, you mean that it makes you feel angry, irritated, or frustrated. Shopping in the January sales can be maddening = infuriating + maddeningly mad·den·ing·ly The service is maddeningly slow. very annoying = infuriating
extremely annoying or displeasing; "his cavelier curtness of manner was exasperating"; "I've had an exasperating day"; "her infuriating indifference"; "the ceaseless tumult of the jukebox was maddening"