If you say that someone went for the jugular, you mean that they strongly attacked another person's weakest points in order to harm them. Mr Black went for the jugular, asking intimate sexual questions
One of the large veins which return the blood from the head to the heart through two chief trunks, an external and an internal, on each side of the neck; called also the jugular vein
[ 'j&-gy&-l&r als ] (adjective.) 1597. From Late Latin jugulāris from Latin iugulum (“neck, throat”) from iugum (“yoke”), from Proto-Indo-European *yugóm.