Sick building syndrome is a group of conditions, including headaches, sore eyes, and tiredness, which people who work in offices may experience because the air there is not healthy to breathe. An illness affecting workers in office buildings, characterized by skin irritations, headache, and respiratory problems, and thought to be caused by indoor pollutants, microorganisms, or inadequate ventilation. Also called building sickness. when chemicals and germs stay in an office building and make the people who work there feel ill