Definition of maddened in English English dictionary
marked by extreme anger; "the enraged bull attached"; "furious about the accident"; "a furious scowl"; "infuriated onlookers charged the police who were beating the boy"; "could not control the maddened crowd"
To madden a person or animal means to make them very angry. He knew that what he was saying did not reach her. And the knowledge of it maddened him = infuriate. to make someone very angry or annoyed