marked by dejection from being alone; "felt sad and lonely"; "the loneliest night of the week"; "lonesome when her husband is away"; "spent a lonesome hour in the bar"
being the only one; single and isolated from others; "the lone doctor in the entire county"; "a lonesome pine"; "an only child"; "the sole heir"; "the sole example"; "a solitary instance of cowardice"; "a solitary speck in the sky"
Someone who is lonesome is unhappy because they do not have any friends or do not have anyone to talk to. I've grown so lonesome, thinking of you. = lonely
A lonesome place is one which very few people come to and which is a long way from places where people live. He was finding the river lonesome. = lonely