If you handcuff someone, you put handcuffs around their wrists. They tried to handcuff him but, despite his injuries, he fought his way free. to put handcuffs on someone
Handcuffs are two metal rings which are joined together and can be locked round someone's wrists, usually by the police during an arrest. He was led away to jail in handcuffs
A fastening, consisting of an iron ring around the wrist, usually connected by a chain with one on the other wrist; a manacle; usually in the plural