anaplasie (zellumformung mit verlust der differenzierungsfähigkeit)

German - English

Definition of anaplasie (zellumformung mit verlust der differenzierungsfähigkeit) in German English dictionary

anaplasia

A reversion of differentiation in cells that is characteristic of malignancy in tumours

{i} loss of structural differentiation of unique features inside a cell or group of cells; dedifferentiation

Replacement of specialized cells by unspecialized, undifferentiated, or stem cells; dedifferentiation

lack of differentiation manifested as abnormal architectural and cytologic features Characteristic cytologic features include nuclear and cellular pleomorphism (variation in size and shape), nuclear hyperchromatism (dark staining), the presence of tumor giant cells (abnormal large cells with lobated, polyploid nuclei), and abnormal mitoses (tripolar or quadripolar nuclear spindles) Characteristic architectural abnormalities include loss of normal orientation of the cells within the tissue both in their relationship to the underlying stroma and to adjacent cells

In the case of a body cell, a reversion to a more primitive condition A term used to denote the alteration in cell character which constitutes malignancy

The loss of structural organization and useful function of a cell

characteristics of a cell identifies it as a cancer cell Malignant

loss of structural differentiation within a cell or group of cells often with increased capacity for multiplication, as in a malignant tumor

Hyphenation

anaplasie (zellumformung MIT verlust der differenzierungsfähigkeit)