If you despair of something, you feel that there is no hope that it will happen or improve. If you despair of someone, you feel that there is no hope that they will improve. He wished to earn a living through writing but despaired of doing so. to feel that there is no hope at all
If you despair, you feel that everything is wrong and that nothing will improve. `Oh, I despair sometimes,' he says in mock sorrow He does despair at much of the press criticism
the feeling that everything is wrong and nothing will turn out well a state in which everything seems wrong and will turn out badly; "they were rescued from despair at the last minute"
To be hopeless; to have no hope; to give up all hope or expectation; often with of
a state in which everything seems wrong and will turn out badly; "they were rescued from despair at the last minute"