{i} device for breaking bone in order to correct a defect; cell which absorbs tissue in order to form bone canals (Medicine)
A cell found in the bone marrow at the junction between the bone marrow and the bone Active myeloma growth stimulates the osteoclast to destroy bone This process is called resorption Normally bone resorption is counterbalanced by the activity of osteoblasts, which create new bone In myeloma, osteoblast activity is blocked The combination of accelerated bone resorption and blocked new bone formation results in lytic lesions