If you are puffed or puffed out, you are breathing with difficulty because you have been using a lot of energy. Do you get puffed out running up and down the stairs? = breathless. breathing quickly because you have been using a lot of energy
abnormally distended especially by fluids or gas; "hungry children with bloated stomachs"; "he had a grossly distended stomach"; "eyes with puffed (or puffy) lids"; "swollen hands"; "tumescent tissue"; "puffy tumid flesh"
If a part of your body is puffed or puffed up, it is swollen because of an injury or because you are unwell. His face was a little puffed = swollen, puffy