Thus, self-directed behavior increases after anxiogenic drug treatment but decreases after anxiolytic drug treatment (29 ).
An anxiogenic substance is one that causes anxiety. Anxiogenic effects can be measured by, for example, the hole-board test in rats and mice.. A number of agents are used to provoke anxiety (anxiogenes) or panic (panicogenes) in experimental models . Some of the most common substances are: DMCM, sodium lactate, carbon dioxide (CO2), caffeine, yohimbine, serotoninergic agents, adrenergic agents and cholecystokinin (CCK)[1]