Of course, there will be a few problems along the way.
emphasis You use of course in order to emphasize a statement that you are making, especially when you are agreeing or disagreeing with someone. `I expect you're right.' --- `Of course I'm right.' `You will strictly observe your diet: no wine or spirits, very little meat.' --- `Of course.'
emphasis Of course not is an emphatic way of saying no. `You're not really seriously considering this thing, are you?' --- `No, of course not.'
formulae You use of course as a polite way of giving permission. `Can I just say something about the cup game on Saturday?' --- `Yes of course you can.' `Could I see these documents?' --- `Of course.'
You say of course to suggest that something is normal, obvious, or well-known, and should therefore not surprise the person you are talking to. Of course there were lots of other interesting things at the exhibition `I have read about you in the newspapers of course,' Charlie said The only honest answer is, of course, yes. = naturally