If you are mystified by something, you find it impossible to explain or understand. The audience must have been totally mystified by the plot There was something strange in her attitude which mystified me. = baffle + mystifying mys·ti·fy·ing I find your attitude a little mystifying, Moira. = puzzling. if something mystifies you, it is so strange or confusing that you cannot understand or explain it = baffle (mystifier, from mystère; MYSTERY PLAY)