A lesion is an injury or wound to someone's body. skin lesions. a lesion of the spinal cord. damage to someone's skin or part of their body such as their stomach or brain, caused by injury or illness (laesio, from laedere )
any damage to tissues of the body due to disease or trauma In the case of functional neurosurgery for movement disorders, a lesion refers to the deliberate destruction of certain cells of the brain causing poor movement control